Most quests adapt to your choices instead of giving hard fails, but you'll want to watch for those time-sensitive missions marked with "No Time to Lose" warnings. The really crucial moments come during For Victory and Oratores, since these lock you out of certain content so save before hitting those points.

Getting through Demons of Trosky before For Victory is pretty important, and keeping an eye on escort missions since those can slip away if you take too long. Maybe interesting: missions like Wedding Crashers branch permanently based on early choices between helping the blacksmith or miller, so think those through.

Always keep some Saviour Schnapps handy for saving before big decisions, and try clearing side content in Trosky and Kuttenburg areas before pushing main story too far. The game actually handles failures pretty well, letting the story flow even if things don't go perfectly, but time-sensitive stuff needs quick attention especially when NPCs are involved.

Something to remember: group missions and NPC escorts should probably be your priority when they pop up, since those tend to have stricter timelines than solo ventures. The whole system's built around rolling with the consequences though, so don't stress too much about perfect runs.