The essential idea is using the quest choices properly, since theyll all come back to affect you later. Really need to think about how you handle miller machal with those experiments, since reporting him changes a lot of quest paths and even gets him killed if youre not careful. Choices about burning down settlements versus finding peaceful solutions make a big difference, and keeping track of who youre helping or betraying matters too cause the npcs definitely remember.

During quests look for different ways to finish them since theres usually multiple paths you can take, and the game locks in most choices so no going back without loading earlier saves. Tip worth noting: even small stuff like dialogue choices or staying quiet affects how people treat you and what quests open up later. Getting into crime or being honorable changes how things play out especially with the endings, and npcs definitely treat you differently based on your reputation. Just remember nearly everything you do has some kind of consequence even if it doesnt seem important at first