Start with the Medium preset as your baseline, then tweak individual settings for optimal results. Lower shadow quality and vegetation detail first, since these hit performance hardest. DLSS Quality or FSR 2 Quality makes a huge difference without sacrificing much visual fidelity, really worth enabling if you've got compatible hardware.

System-side optimizations are straightforward but essential, make sure you're running off an NVMe SSD, and disable background processes especially Game Bar and Xbox overlays. For Nvidia users, force threaded optimization on and set power management to max performance, AMD folks should definitely enable FSR 3 with Frame Generation.

Tip: the DXVK async mod from Nexus really helps with DX12 stability, and keeping shader quality at Medium gives you good visuals without tanking framerates. If you've got 32GB RAM you can push some settings higher, but stick to Medium global illumination and volumetric effects regardless of your setup. Watch out for those Experimental settings, they need seriously beefy hardware like a 4080 or better to run smoothly.