During Act 1 you'll encounter your first major Urge moment at the portal sequence, where you can choose to sever Gale's hand - timing this decision is crucial since it locks you out of having him as a companion. When you reach the Druid Grove check your interaction with Timber while Speak with Animals divination isn't active, the murder option triggers specific dialogue paths that shape your character's development. The real test comes at camp where Alfira's death sequence plays out automatically leading to some interesting gear drops including the Deathstalker Mantle.

Throughout the main story you'll notice unique dialogue choices popping up that reflect your murderous nature, particularly during key moments like the Arabella encounter where positioning and timing affect how things play out. The Last Light Inn sequence needs careful consideration since killing Isobel drops the barrier instantly and changes the whole area's dynamics. Watch for the romance partner sequence in Act 2, where resisting the urge requires specific dialogue choices and careful timing to avoid triggering the murder outcome.

The big revelation hits in Act 3 when everything connects to Bhaal - your actions leading up to this point determine available options especially during the Orin confrontation. The murder essence mechanics become more complex here so pay attention to your previous choices as they directly impact which endings remain accessible. Maybe interesting to note that companion reactions shift dramatically based on how many urges you've given in to throughout the story