Not possible to get every legendary item in one run. Start by understanding mutually exclusive choices, particularly with shadowheart's quest line where you'll need to pick between selûne's or shar's spear, can't have both. Different factions like the harpers give unique rewards, so joining one locks you out of others. Some legendary gear requires specific areas that become inaccessible after certain choices, like items in the wyrmway versus house of hope

Watch for companion-specific rewards too, since picking certain allies blocks others and their associated items. Definitely keep an eye on hidden triggers, especially for rare finds like nyrulna which needs specific event chains completed. Tip: you'll need about 3 different playthroughs to see all 34 legendary items, but you can grab around 15-20 per run if you plan carefully

Remember that some legendaries are tied to specific quest outcomes, and you'll have to make tough choices about which path to follow. Your alignment and story decisions matter here, so think carefully about which legendary items fit your character build best