The early campaign is pretty forgiving with no xp loss until act 6, which gives you time to learn the core mechanics without stress. Your positioning matters though since dying resets the zone with fresh enemies and youll lose any uncollected loot on the ground. Once you hit act 6, deaths start costing 5% of your level progress, so that's when you need to watch your defensive layers more carefully and time your movement skills properly.

The real challenge kicks in during endgame atlas content where each death takes 10% of your XP bar and instantly fails the map. Keep a close eye on your waystone count since you'll need a fresh one after each failed attempt. Something interesting about the map mechanics - your character's position relative to dangerous ground effects becomes crucial especially during boss phases, since one slip-up means losing all map modifiers and having to start fresh. For tougher content, try maintaining about 2-3 screen lengths from deadly mechanics while keeping track of enemy telegraph animations, this gives you enough reaction time without sacrificing damage uptime.