Getting your psi protection sorted is the first real challenge here check out the cuirass exoskeleton or seva suit if you can find them they'll help tons with those nasty emissions. The observatory's gonna be your main headache, look for that lit-up back entrance leading down to those tunnels with electrical anomalies moving around. Tip: sprint between the anomalies when they drift apart, and you'll save yourself some medkits.

Once you make it to the beacon chamber, you've got two ways to handle it - either blast the beacon right away to stop those weird hallucinations, or if you're feeling thorough, disable the antenna system first for some extra rewards. Places like burnt farmstead or pumping station are always rough, those psi-spawned enemies will mess with your head but remember they can't actually hurt you directly.

Good to know - keep your suit in good shape and stock up on ammo before heading out, cause while those phantom enemies aren't real, the environmental damage and actual hostiles definitely are. Maybe interesting - taking out the beacon first usually makes clearing the rest of the area way easier, since you won't be dealing with those hallucinations on top of everything else.