So theres a few really important story moments you gotta watch out for if you want to experience everything. The biggest one is probably taking down maliketh in crumbling farum azula, cause once you do that the capital city completely changes and you cant go back. Learned that one the hard way when i was trying to finish up some quests!

Its also worth knowing that once you use the forge to burn the erdtree, some questlines can get messed up, especially if youre working on goldmask and brother corhyn's stuff. And if youre doing the volcano manor content, definitely finish those assassination contracts before fighting rykard, or theyll all disappear on you.

For anyone playing the dlc, just keep in mind that burning the sealing tree is another big moment that locks you out of stuff. Pretty much works the same way as the main game - once its done, some quests and areas are just gone until your next playthrough. Honestly, the best way to handle all this is to really explore each area thoroughly before moving forward with the story, especially places like the capital and volcano manor. Trust me, its way better than realizing you missed something and having to wait for new game+!