So i've messed around with those ultimate quickhacks quite a bit and heres what i've found - they're not nearly as powerful against bosses as you might think. Like, you cant just hit them with cyberpsychosis and watch them go crazy or make them off themselves with suicide which is kinda disappointing at first, but makes sense when you think about it.

What i've found works way better is mixing up your approach. Short circuit and overheat are pretty reliable for consistent damage, and if you really wanna get fancy, theres this neat combo with memory wipe, reboot optics and sonic shock that can actually mess bosses up pretty bad. Sometimes i'll start with cyberware malfunction to weaken them up, then hit em with some good old fashioned bullets while they're vulnerable.

The thing about ultimate quickhacks is that while they might not instantly drop bosses like regular enemies, they're still super useful for setting up bigger plays. Just gotta be a bit more creative with how you use them, ya know? I usually save my ram for the more reliable combat hacks, since those big ultimate ones take forever to cool down anyway and sometimes barely do anything to the tougher enemies.