Hit up pacifica first, grand imperial mall and coastview got a steady stream of targets coming back after fast travel really good for quick runs. Valentino alley over in heywood works too, decent for cyberware capacity shards, but watch those gang members they pack some heat. If you've got the expansion, dogtown near golden pacific marker is where the real action's at, specially with those supply drops giving top-tier gear.

Sleep at megabuilding h10 for that sweet skill boost first, makes the whole thing way more worth it. Fast travel's your friend here just clear out a spot, bounce to another area and head back when you need respawns. Pretty straightforward but kinda takes you out of the story vibe if that matters to you.

Tip: those dogtown supply drops always pack tier 5 stuff so might be worth hitting those while you're at it