Here's the bottom line: no return fights with cyberpsychos once cleared. Each sighting links to regina's specific missions functioning as one-time events only. When you handle a cyberpsycho, scan area details, and report back to regina, that location stays permanently cleared. Different from regular gang fights that pop up again these special encounters are designed as unique challenges per run.

Tip: while random ncpd alerts and street conflicts keep happening around night city, cyberpsycho missions are specifically crafted as singular experiences for maximum impact. Worth noting that quest completion tracking is solid here, so once you wrap up with regina, that particular cyberpsycho won't show up again in that spot

Regular respawning stuff like gang activities might make you think these reset too but nope regina's cyberpsycho cases are strictly one-and-done deals