Starting with judy's storyline you'll want to watch out for ex-factor, since turning her down there cuts off the whole friendship path. When she calls for help, definitely say yes and later during pisces, avoid siding with maiko if you care about keeping things good with judy.

For the new phantom liberty content, don't ignore those first urgent calls about the president, especially dog eat dog. The game actually fails you if you take too long there which is pretty serious compared to most other missions. Something interesting about firestarter too - make a save before jumping in since your choices stick permanently.

Most regular missions give you plenty of time to explore and do other stuff first, but there are some tricky exceptions worth noting. That nomad mission fortunate son has a hidden 24-hour timer for delivering the kidney, and poor scooter dies if you're late. The cop barry's situation during happy together can also end badly if you leave it hanging too long. Tip for romance paths - it's more about making the right choices during conversations than rushing through them, especially with judy where staying against maiko matters a lot. Maybe grab a quick save before any big story moments in phantom liberty, since that dlc doesnt mess around with permanent outcomes.