The most important change to understand is how attributes work differently now. Instead of worrying about skill-based multipliers, you get 12 virtue points every time you level up which lets you improve stats however you want. Endurance works better than before, since it updates your health retroactively and helps you regenerate when out of combat, though personality is still pretty weak because of how the disposition system works.

Something interesting about luck - it needs 4 points for each upgrade which makes it a bit more expensive than other attributes. The old system where you had to carefully plan skill increases is completely gone, so you don't need to stress about maximizing those attribute bonuses anymore. Just focus on building the character you want and the virtue points will let you develop naturally, with endurance giving health boosts whenever you increase it, making early-game choices less punishing.